ALK

Across TCGA cell cohorts, ALK mutation is significantly associated with the RNA expression of many other genes, with 876 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALK-associated genes across cancer lineages are CBY1, NOL9, and GRK7. Each is linked with ALK in more than 2 cancer types. Because this analysis shows association rather than direction, both ALK-to-partner and partner-to-ALK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by ALK-low versus ALK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALK→partner) and Y-score (partner→ALK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.546	+3.482	<.001	<.001	3	3
LARGE_INTESTINE	NOL9 →	+0.604	+1.891	<.001	<.001	3	3
LUNG_NSCLC_LUAD	GRK7 →	+0.043	+2.002	<.001	.003	3	3
SKIN	P3H3 →	-1.616	-3.169	.001	.006	3	2
SKIN	HINT3 →	+0.486	+2.523	.001	.003	3	2
SKIN	HPCAL1 →	-1.302	-2.371	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 876 associations by consensus.

CBY1 by ALK expression — LARGE_INTESTINE

Explore this box plot interactively →