ALG8

Across TCGA patient cohorts, ALG8 mutation is significantly associated with the RNA expression of many other genes, with 1,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG8-associated genes across cancer lineages are RPSAP38, SYPL1P1, and MIR599. Each is linked with ALG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG8-to-partner and partner-to-ALG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP38 grouped by ALG8-low versus ALG8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG8→partner) and Y-score (partner→ALG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPSAP38 →	+0.658	+4.962	<.001	.002	3	2
COAD	SYPL1P1 →	+0.121	+4.693	<.001	.007	3	2
CESC	MIR599 →	+0.212	+4.144	<.001	.009	3	2
CESC	MKX-AS1 →	+0.146	+3.797	.005	.005	3	2
CESC	VDAC1P10 →	+0.041	+3.922	<.001	.003	3	2
LUAD	RNU2-65P →	+0.742	+4.598	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,076 associations by consensus.

RPSAP38 by ALG8 expression — LUAD

Explore this box plot interactively →