ALG6

Across TCGA cell cohorts, ALG6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALG6-associated genes across cancer lineages are GRM1, OR4F21, and RAB44. Each is linked with ALG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG6-to-partner and partner-to-ALG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM1 grouped by ALG6-low versus ALG6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG6→partner) and Y-score (partner→ALG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM1 →	+0.045	+3.750	<.001	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.139	+2.878	<.001	.009	3	1
LARGE_INTESTINE	RAB44 →	+0.112	+3.520	<.001	.005	3	1
LARGE_INTESTINE	IRAK3 →	+0.708	+3.421	<.001	.008	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.038	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GRM1 by ALG6 expression — LARGE_INTESTINE

Explore this box plot interactively →