Across TCGA patient cohorts, ALG1L mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG1L-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with ALG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG1L-to-partner and partner-to-ALG1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1L→partner) and Y-score (partner→ALG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.373	-3.459	.003	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.235	-3.446	.005	.005	3	1
UCEC	Ku80 →	+0.240	+2.335	.043	.020	3	1
UCEC	NDRG1_pT346 →	-0.485	-2.321	.049	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.495	-3.000	.028	.036	3	1
UCEC	p70-S6K_pT389 →	-0.257	-3.169	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ALG1L survival (RNA) · tumor vs normal (RNA) · all ALG1L data types