ALG14

Across TCGA patient cohorts, ALG14 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG14-associated genes across cancer lineages are Notch1, ACC1, and Ku80. Each is linked with ALG14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG14-to-partner and partner-to-ALG14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ALG14-low versus ALG14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG14→partner) and Y-score (partner→ALG14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.160	+3.000	.049	.037	3	2
UCEC	ACC1 →	+0.520	+3.000	.013	.037	3	1
UCEC	Ku80 →	+0.333	+3.013	.014	.019	3	1
UCEC	MEK1_p_S217_S221 →	-0.336	-3.000	.033	.037	2	1
UCEC	C-Raf →	+0.253	+3.000	.002	.037	2	1
UCEC	Di-Ras3 →	-0.191	-3.000	.026	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by ALG14 expression — UCEC

Explore this box plot interactively →