ALG11

Across TCGA patient cohorts, ALG11 mutation is significantly associated with the RNA expression of many other genes, with 1,549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG11-associated genes across cancer lineages are MIR1268B, SNX3P1Y, and RN7SL420P. Each is linked with ALG11 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALG11-to-partner and partner-to-ALG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1268B grouped by ALG11-low versus ALG11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG11→partner) and Y-score (partner→ALG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR1268B →	+0.879	+4.425	<.001	.006	3	3
UCEC	SNX3P1Y →	+0.084	+4.230	<.001	.004	3	2
HNSC	RN7SL420P →	+0.193	+4.505	<.001	.009	3	2
HNSC	CXCL1P1 →	+0.131	+6.132	<.001	.001	3	2
BRCA	RNU6-582P →	+0.361	+8.471	<.001	.005	3	1
BRCA	SNORD115-30 →	+0.448	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,549 associations by consensus.

MIR1268B by ALG11 expression — HNSC

Explore this box plot interactively →