ALG10

Across TCGA cell cohorts, ALG10 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALG10-associated genes across cancer lineages are ACER1, OR2C1, and LONRF2. Each is linked with ALG10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG10-to-partner and partner-to-ALG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by ALG10-low versus ALG10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG10→partner) and Y-score (partner→ALG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.070	+3.145	.005	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.129	+4.310	<.001	<.001	3	1
LARGE_INTESTINE	LONRF2 →	+0.503	+3.392	<.001	.006	3	1
LARGE_INTESTINE	NUPR2 →	+0.205	+2.688	.001	.008	3	1
LARGE_INTESTINE	SPESP1 →	+0.556	+3.906	.005	.001	3	1
LARGE_INTESTINE	DUX4 →	+0.049	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ACER1 by ALG10 expression — LARGE_INTESTINE

Explore this box plot interactively →