ALG1

Across TCGA patient cohorts, ALG1 mutation is significantly associated with the RNA expression of many other genes, with 1,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG1-associated genes across cancer lineages are RN7SL248P, RNA5SP415, and RN7SL134P. Each is linked with ALG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALG1-to-partner and partner-to-ALG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by ALG1-low versus ALG1-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1→partner) and Y-score (partner→ALG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RN7SL248P →	+0.245	+5.297	<.001	.006	3	3
UCEC	RNA5SP415 →	+0.549	+2.225	<.001	.008	3	3
UCEC	RN7SL134P →	+0.130	+2.336	<.001	.006	3	2
ESCA	RNA5SP403 →	+0.758	+5.450	<.001	.004	3	2
ESCA	HMGN1P19 →	+0.703	+5.247	<.001	.006	3	2
BLCA	RNA5SP276 →	+0.619	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

RN7SL248P by ALG1 expression — OV

Explore this box plot interactively →