ALG1

Across TCGA cell cohorts, ALG1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALG1-associated genes across cancer lineages are KRT35, SLCO1C1, and FAM205A. Each is linked with ALG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG1-to-partner and partner-to-ALG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT35 grouped by ALG1-low versus ALG1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG1→partner) and Y-score (partner→ALG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT35 →	+0.136	+5.643	<.001	.002	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.533	+3.842	<.001	.001	3	1
LARGE_INTESTINE	FAM205A →	+0.023	+3.029	<.001	.003	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.021	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

KRT35 by ALG1 expression — BLOOD_Lymphoma

Explore this box plot interactively →