ALDOC

Across TCGA patient cohorts, ALDOC mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDOC-associated genes across cancer lineages are HPRT1P2, RNA5SP414, and RNA5SP411. Each is linked with ALDOC in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDOC-to-partner and partner-to-ALDOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPRT1P2 grouped by ALDOC-low versus ALDOC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDOC→partner) and Y-score (partner→ALDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HPRT1P2 →	+0.074	+3.750	<.001	.002	3	2
UCEC	RNA5SP414 →	+0.739	+2.769	<.001	.002	3	1
UCEC	RNA5SP411 →	+1.717	+2.393	<.001	.005	3	1
UCEC	RNA5SP412 →	+1.023	+3.452	<.001	<.001	3	1
COAD	OR4L1 →	+0.079	+7.741	<.001	.009	3	1
SKCM	RNU5E-3P →	+0.489	+6.328	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

HPRT1P2 by ALDOC expression — UCEC

Explore this box plot interactively →