ALDH8A1

Across TCGA pan-cancer cohorts, ALDH8A1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ALDH8A1 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher ALDH8A1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDH8A1 expression acts as an unfavorable survival marker.

PRAD, UCEC, and LUAD are the cancer types where ALDH8A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	III,IV	0.435	0.688	.002	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ALDH8A1–PRAD (DFS)

Open the PRAD breakdown →