ALDH8A1

Across TCGA pan-cancer cohorts, ALDH8A1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ALDH8A1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ALDH8A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ALDH8A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC and LSCC are the cancer types where ALDH8A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.979	0.826	.003	30	view →
LSCC	DFS	Median	All	0.517	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ALDH8A1–CCRCC (DFS)

Open the CCRCC breakdown →