ALDH8A1

Across TCGA patient cohorts, ALDH8A1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH8A1-associated genes across cancer lineages are CDK1, PCNA, and Bid. Each is linked with ALDH8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH8A1-to-partner and partner-to-ALDH8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by ALDH8A1-low versus ALDH8A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH8A1→partner) and Y-score (partner→ALDH8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CDK1 →	+0.143	+2.179	.020	.035	3	2
UCEC	PCNA →	+0.191	+2.459	.032	.019	3	2
LUSC	Bid →	+0.225	+3.331	<.001	.005	3	1
LUAD	XRCC1 →	+0.178	+2.832	.015	.034	3	1
UCEC	ERK2 →	+0.163	+2.000	.040	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.146	-3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CDK1 by ALDH8A1 expression — LUSC

Explore this box plot interactively →