ALDH8A1

Across TCGA cell cohorts, ALDH8A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,919 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALDH8A1-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Regulation of macroautophagy, and Regulation of myoblast fusion. Each is linked with ALDH8A1 in more than 8 cancer types. Because this analysis shows association rather than direction, both ALDH8A1-to-partner and partner-to-ALDH8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by ALDH8A1-low versus ALDH8A1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH8A1→partner) and Y-score (partner→ALDH8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.102	+0.716	.003	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.083	+0.344	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.118	+0.440	<.001	<.001	3	9
KIDNEY	Cytoplasmic translation →	+0.070	+0.636	.001	<.001	3	9
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.156	+0.457	.001	.001	3	8
KIDNEY	Process utilizing autophagic mechanism →	+0.062	+0.654	.002	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,919 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by ALDH8A1 expression — KIDNEY

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