ALDH4A1

Across TCGA pan-cancer cohorts, ALDH4A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALDH4A1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALDH4A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ALDH4A1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where ALDH4A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	1.000	0.825	.002	26	view →
GBM	DFS	Quartile	All	0.207	0.482	.012	10	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	10	view →
UCEC	OS	Median	III,IV	1.000	0.494	.016	8	view →
HNSC	OS	Median	All	1.000	0.449	.023	8	view →
LUAD	DFS	Quartile	All	1.000	0.875	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALDH4A1–LSCC (DFS)

Open the LSCC breakdown →