ALDH4A1

Across TCGA pan-cancer cohorts, ALDH4A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ALDH4A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ALDH4A1 RNA is repressed in tumor relative to normal tissue. In most cancer types ALDH4A1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where ALDH4A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALDH4A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−3.784	<.001	11	view →
COAD	Female	II,III,IV	+2.041	<.001	11	view →
THCA	Male	IV	−2.006	<.001	11	view →
KIRP	All	III,IV	−2.150	<.001	10	view →
KIRC	Male	All	−1.614	<.001	10	view →
LUSC	Female	II,III,IV	+1.202	<.001	7	view →
BRCA	All	II,III,IV	−0.952	<.001	6	view →
READ	All	All	+1.497	<.001	5	view →
LIHC	All	All	−0.427	.004	5	view →
CHOL	Male	All	−2.693	<.001	3	view →
HNSC	Male	IV	−0.567	.024	2	view →
PRAD	All	All	−0.314	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ALDH4A1–KICH

Open the KICH breakdown →