ALDH4A1

Across TCGA patient cohorts, ALDH4A1 mutation is significantly associated with the RNA expression of many other genes, with 1,821 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH4A1-associated genes across cancer lineages are IFNA10, CCL5, and TAF9. Each is linked with ALDH4A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH4A1-to-partner and partner-to-ALDH4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA10 grouped by ALDH4A1-low versus ALDH4A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH4A1→partner) and Y-score (partner→ALDH4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFNA10 →	+0.027	+5.153	<.001	.001	3	3
UCEC	CCL5 →	+1.189	+2.665	<.001	<.001	3	2
UCEC	TAF9 →	+0.568	+2.263	<.001	<.001	3	2
UCEC	CCL4 →	+0.705	+2.284	.002	<.001	3	2
UCEC	CCL18 →	+1.095	+2.423	.002	.001	3	2
UCEC	TUBGCP5 →	+0.397	+1.970	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,821 associations by consensus.

IFNA10 by ALDH4A1 expression — COAD

Explore this box plot interactively →