ALDH4A1

Across TCGA patient cohorts, ALDH4A1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH4A1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and Akt_pT308. Each is linked with ALDH4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH4A1-to-partner and partner-to-ALDH4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ALDH4A1-low versus ALDH4A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH4A1→partner) and Y-score (partner→ALDH4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.305	-2.247	<.001	.001	3	2
UCEC	INPP4B →	-0.300	-2.000	.011	.029	3	2
UCEC	Akt_pT308 →	+0.461	+1.874	.046	.049	3	2
COAD	Stathmin →	+0.172	+2.815	.042	.036	3	1
COAD	4E-BP1_pT70 →	+0.143	+2.815	.030	.036	3	1
UCEC	14-3-3_beta →	-0.112	-2.673	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

EGFR_pY1068 by ALDH4A1 expression — UCEC

Explore this box plot interactively →