ALDH4A1

Across TCGA cell cohorts, ALDH4A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,213 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ALDH4A1-associated GO terms across cancer lineages are L-proline catabolic process, Organic acid catabolic process, and Carboxylic acid catabolic process. Each is linked with ALDH4A1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ALDH4A1-to-partner and partner-to-ALDH4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-proline catabolic process grouped by ALDH4A1-low versus ALDH4A1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH4A1→partner) and Y-score (partner→ALDH4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	L-proline catabolic process →	+1.469	+1.764	<.001	<.001	3	20
LIVER	Organic acid catabolic process →	+0.074	+1.723	.002	.001	3	11
LIVER	Carboxylic acid catabolic process →	+0.074	+1.723	.002	.001	3	11
BREAST	Branched-chain amino acid metabolic process →	+0.114	+1.717	<.001	<.001	3	10
STOMACH	Regulation of ATPase-coupled calcium transmembrane transporter activity →	-0.211	-1.037	.002	.006	2	10
BREAST	Urokinase plasminogen activator signaling pathway →	-1.017	-1.346	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

L-proline catabolic process by ALDH4A1 expression — URINARY_TRACT

Explore this box plot interactively →