ALDH4A1

Across TCGA cell cohorts, ALDH4A1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDH4A1-associated genes across cancer lineages are P2RY13, EXOC1L, and UGT2B10. Each is linked with ALDH4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH4A1-to-partner and partner-to-ALDH4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY13 grouped by ALDH4A1-low versus ALDH4A1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH4A1→partner) and Y-score (partner→ALDH4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	P2RY13 →	+0.006	+4.684	<.001	.002	3	2
SKIN	EXOC1L →	+0.093	+5.217	<.001	<.001	3	2
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
SKIN	STATH →	+0.280	+5.217	<.001	<.001	3	1
SKIN	CSN2 →	+0.091	+4.415	<.001	.007	3	1
SKIN	GUCA2A →	+0.052	+4.273	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

P2RY13 by ALDH4A1 expression — SKIN

Explore this box plot interactively →