ALDH3B2

Across TCGA patient cohorts, ALDH3B2 mutation is significantly associated with the RNA expression of many other genes, with 989 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH3B2-associated genes across cancer lineages are OR1A1, MFSD12, and NIPA1. Each is linked with ALDH3B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH3B2-to-partner and partner-to-ALDH3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1A1 grouped by ALDH3B2-low versus ALDH3B2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH3B2→partner) and Y-score (partner→ALDH3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR1A1 →	+0.045	+5.124	.001	.008	3	3
UCEC	MFSD12 →	+0.445	+2.522	.001	.009	3	2
UCEC	NIPA1 →	+0.667	+2.021	<.001	.001	3	2
UCEC	RRM2 →	+0.660	+2.330	.006	.003	3	2
UCEC	PPP2R2D →	+0.277	+2.648	.003	.005	3	2
SKCM	POLE →	+0.414	+1.925	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 989 associations by consensus.

OR1A1 by ALDH3B2 expression — HNSC

Explore this box plot interactively →