ALDH1L1-AS2

Across TCGA pan-cancer cohorts, ALDH1L1-AS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ALDH1L1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALDH1L1-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types ALDH1L1-AS2 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, BRCA, and KIRP are the cancer types where ALDH1L1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALDH1L1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.580	<.001	9	view →
BRCA	All	III,IV	−1.409	<.001	6	view →
KIRP	Male	III,IV	−1.027	.001	6	view →
KIRC	Male	All	−0.701	<.001	6	view →
STAD	All	All	−0.176	.001	6	view →
CHOL	Male	All	−0.873	<.001	4	view →
LUAD	All	All	−0.075	.004	4	view →
LIHC	Male	All	+0.725	<.001	3	view →
COAD	Female	All	−0.211	.003	3	view →
LUSC	Female	II,III,IV	−0.098	.028	3	view →
PRAD	All	All	−0.710	<.001	2	view →
UCEC	All	IV	+0.630	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ALDH1L1-AS2–HNSC

Open the HNSC breakdown →