ALDH1A2

Across TCGA patient cohorts, ALDH1A2 mutation is significantly associated with the RNA expression of many other genes, with 2,296 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1A2-associated genes across cancer lineages are SEC13, GMEB1, and FEN1. Each is linked with ALDH1A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH1A2-to-partner and partner-to-ALDH1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by ALDH1A2-low versus ALDH1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1A2→partner) and Y-score (partner→ALDH1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.348	+3.491	.002	.002	3	3
UCEC	GMEB1 →	+0.303	+3.375	.008	.004	3	3
UCEC	FEN1 →	+0.519	+3.906	.008	<.001	3	3
UCEC	LSM3 →	+0.531	+2.321	.001	.001	3	3
UCEC	NDUFAB1 →	+0.518	+2.860	<.001	<.001	3	3
UCEC	MRTO4 →	+0.345	+4.016	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,296 associations by consensus.

SEC13 by ALDH1A2 expression — UCEC

Explore this box plot interactively →