ALDH18A1

Across TCGA cell cohorts, ALDH18A1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ALDH18A1-associated genes across cancer lineages are FBXO40, DCSTAMP, and SMIM9. Each is linked with ALDH18A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH18A1-to-partner and partner-to-ALDH18A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO40 grouped by ALDH18A1-low versus ALDH18A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH18A1→partner) and Y-score (partner→ALDH18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FBXO40 →	+0.006	+5.189	<.001	<.001	3	2
LUNG_NSCLC_LUAD	DCSTAMP →	+0.122	+4.734	<.001	.002	3	2
BLOOD_Lymphoma	SMIM9 →	+0.124	+4.867	<.001	.009	3	1
BLOOD_Leukemia	NPFFR1 →	+0.008	+2.774	.005	.006	3	1
BLOOD_Leukemia	KSR2 →	+0.276	+3.061	.003	.003	3	1
BLOOD_Leukemia	KHDC3L →	+0.158	+3.829	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FBXO40 by ALDH18A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →