ALCAM

Across TCGA cell cohorts, ALCAM mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ALCAM-associated genes across cancer lineages are ACER1, OR52N5, and TXNDC8. Each is linked with ALCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ALCAM-to-partner and partner-to-ALCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by ALCAM-low versus ALCAM-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALCAM→partner) and Y-score (partner→ALCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACER1 →	+0.046	+3.795	.001	.004	3	2
LUNG_NSCLC_LUAD	OR52N5 →	+0.130	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TXNDC8 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52E6 →	+0.206	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACER1 by ALCAM expression — BLOOD_Lymphoma

Explore this box plot interactively →