ALAD

Across TCGA cell cohorts, ALAD mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ALAD-associated genes across cancer lineages are ODF4, FAM47C, and SPINK9. Each is linked with ALAD in more than 1 cancer types. Because this analysis shows association rather than direction, both ALAD-to-partner and partner-to-ALAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF4 grouped by ALAD-low versus ALAD-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAD→partner) and Y-score (partner→ALAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	SPINK9 →	+0.065	+5.415	<.001	.004	3	1
LARGE_INTESTINE	YIPF7 →	+0.074	+3.878	<.001	.003	3	1
LARGE_INTESTINE	GRM1 →	+0.031	+3.750	.007	.007	2	1
LARGE_INTESTINE	OR2A14 →	+0.036	+3.788	.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ODF4 by ALAD expression — SKIN

Explore this box plot interactively →