AKTIP

Across TCGA pan-cancer cohorts, AKTIP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AKTIP data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher AKTIP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AKTIP expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, GBM, and UCEC are the cancer types where AKTIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.430	0.901	.017	10	view →
GBM	OS	Tertile	All	0.235	0.506	.007	5	view →
UCEC	DFS	Median	III,IV	0.494	0.905	.044	4	view →
HNSC	OS	Tertile	All	0.902	0.787	.038	4	view →
LUAD	OS	Tertile	III,IV	1.000	0.649	.022	1	view →
CCRCC	DFS	Tertile	All	1.000	0.686	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AKTIP–LSCC (OS)

Open the LSCC breakdown →