AKTIP

Across TCGA patient cohorts, AKTIP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKTIP-associated genes across cancer lineages are ATM, p38-MAPK_pT180_Y182, and EGFR_pY1068. Each is linked with AKTIP in more than 2 cancer types. Because this analysis shows association rather than direction, both AKTIP-to-partner and partner-to-AKTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AKTIP-low versus AKTIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKTIP→partner) and Y-score (partner→AKTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.602	-3.156	.002	.018	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.506	-2.102	.009	.019	3	2
UCEC	EGFR_pY1068 →	-0.324	-2.807	.003	.003	3	1
UCEC	FoxM1 →	+0.291	+2.807	.010	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-2.449	.018	.019	3	1
UCEC	GATA6 →	-0.164	-2.800	.015	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by AKTIP expression — UCEC

Explore this box plot interactively →