AKT3

Across TCGA patient cohorts, AKT3 mutation is significantly associated with the RNA expression of many other genes, with 2,375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKT3-associated genes across cancer lineages are TBR1, RNU6-662P, and RNA5SP480. Each is linked with AKT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKT3-to-partner and partner-to-AKT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by AKT3-low versus AKT3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT3→partner) and Y-score (partner→AKT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBR1 →	+0.186	+3.408	.003	.007	3	2
LUAD	RNU6-662P →	+0.244	+3.217	<.001	.008	3	2
LUAD	RNA5SP480 →	+0.127	+4.792	<.001	.002	3	2
SKCM	RN7SKP60 →	+0.159	+4.469	<.001	.006	3	2
SKCM	MIR4510 →	+0.234	+5.485	<.001	.001	3	2
READ	FOXO1B →	+0.146	+5.039	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,375 associations by consensus.

TBR1 by AKT3 expression — LUAD

Explore this box plot interactively →