AKT3

Across TCGA patient cohorts, AKT3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKT3-associated genes across cancer lineages are ACC1, Caspase-7-cleavedD198, and Notch1. Each is linked with AKT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKT3-to-partner and partner-to-AKT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by AKT3-low versus AKT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT3→partner) and Y-score (partner→AKT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.277	+1.750	.028	.049	3	3
UCEC	Caspase-7-cleavedD198 →	+0.610	+2.242	.002	.005	3	3
UCEC	Notch1 →	+0.189	+4.013	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.461	+1.440	.001	.024	3	2
UCEC	TFRC →	+0.398	+2.459	.030	.018	3	2
UCEC	14-3-3_beta →	-0.085	-2.195	.015	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ACC1 by AKT3 expression — UCEC

Explore this box plot interactively →