AKT2

Across TCGA patient cohorts, AKT2 mutation is significantly associated with the RNA expression of many other genes, with 2,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKT2-associated genes across cancer lineages are SHMT2, BTBD6, and VPS18. Each is linked with AKT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKT2-to-partner and partner-to-AKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHMT2 grouped by AKT2-low versus AKT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT2→partner) and Y-score (partner→AKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHMT2 →	+0.606	+2.928	<.001	<.001	3	3
UCEC	BTBD6 →	+0.345	+2.284	.001	<.001	3	3
UCEC	VPS18 →	+0.560	+2.928	<.001	<.001	3	3
THCA	GPC5-AS2 →	+0.109	+6.120	<.001	.002	3	2
THCA	DYNLL1P6 →	+0.148	+6.017	<.001	.002	3	2
THCA	SCGB1D4 →	+0.096	+5.514	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,382 associations by consensus.

SHMT2 by AKT2 expression — UCEC

Explore this box plot interactively →