AKT2

Across TCGA pan-cancer cohorts, AKT2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated AKT2 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher AKT2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AKT2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

ACC, BRCA, and UCEC are the cancer types where AKT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.363	0.794	<.001	102	view →
BRCA	OS	Median	All	0.950	0.900	.002	61	view →
UCEC	OS	Median	All	0.832	0.909	.001	60	view →
LGG	DFS	Median	All	0.631	0.845	<.001	54	view →
UCS	DFS	Median	III,IV	0.629	0.211	<.001	44	view →
HNSC	DFS	Tertile	All	0.765	0.625	<.001	42	view →
CESC	DFS	Tertile	All	0.747	0.878	.005	36	view →
LUAD	DFS	Median	All	0.745	0.866	<.001	36	view →
LUSC	DFS	Quartile	III,IV	0.149	0.574	<.001	36	view →
ESCA	OS	Quartile	All	0.801	0.541	.003	28	view →
OV	OS	Median	III,IV	0.799	0.869	.004	28	view →
SKCM	DFS	Quartile	III,IV	0.371	0.758	.003	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

AKT2–ACC (DFS)

Open the ACC breakdown →