AKT2

Across TCGA patient cohorts, AKT2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKT2-associated genes across cancer lineages are ASNS, p62 Lck ligand, and Annexin-1. Each is linked with AKT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKT2-to-partner and partner-to-AKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by AKT2-low versus AKT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT2→partner) and Y-score (partner→AKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.641	+3.169	.006	.019	3	4
UCEC	p62 Lck ligand →	+0.327	+2.807	.005	<.001	3	3
UCEC	Annexin-1 →	+0.701	+3.807	<.001	<.001	3	3
UCEC	MEK1 →	+0.413	+3.087	.001	<.001	3	2
UCEC	ATM →	-0.465	-2.321	.004	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.599	+3.008	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ASNS by AKT2 expression — SKCM

Explore this box plot interactively →