AKT2

Across TCGA cell cohorts, AKT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,182 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKT2-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with AKT2 in more than 16 cancer types. Because this analysis shows association rather than direction, both AKT2-to-partner and partner-to-AKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by AKT2-low versus AKT2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT2→partner) and Y-score (partner→AKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.086	+1.330	<.001	<.001	3	17
STOMACH	Heterochromatin formation →	+0.067	+1.148	.003	<.001	3	17
STOMACH	Epigenetic regulation of gene expression →	+0.079	+1.310	.003	.002	3	16
STOMACH	Heterochromatin organization →	+0.065	+1.115	.003	<.001	3	16
STOMACH	Negative regulation of chromosome condensation →	+0.192	+1.343	<.001	.001	3	16
BONE	Negative regulation of gene expression, epigenetic →	+0.089	+0.754	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,182 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by AKT2 expression — STOMACH

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