AKT2

Across TCGA cell cohorts, AKT2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AKT2-associated genes across cancer lineages are ADAM2, BIRC8, and OR2T2. Each is linked with AKT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKT2-to-partner and partner-to-AKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by AKT2-low versus AKT2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT2→partner) and Y-score (partner→AKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAM2 →	+0.006	+6.022	<.001	.001	3	1
SKIN	BIRC8 →	+0.012	+4.977	<.001	.007	3	1
SKIN	OR2T2 →	+0.013	+4.977	<.001	.007	3	1
LUNG_SCLC	IFNA10 →	+0.186	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ADAM2 by AKT2 expression — SKIN

Explore this box plot interactively →