AKT1

Across TCGA patient cohorts, AKT1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,348 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AKT1-associated genes across cancer lineages are TMED10, ZFYVE21, and TMX1. Each is linked with AKT1 in more than 7 cancer types. Because this analysis shows association rather than direction, both AKT1-to-partner and partner-to-AKT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKT1 versus TMED10 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT1→partner) and Y-score (partner→AKT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMED10 →	+0.618	+0.404	<.001	<.001	3	8
BRCA	ZFYVE21 →	+0.526	+0.270	<.001	<.001	3	7
OV	TMX1 →	+0.619	+0.372	.002	.002	3	7
OV	BAG5 →	+0.621	+0.352	<.001	.003	3	7
COAD	PPP2R5C →	+0.443	+0.237	.004	<.001	3	7
LUAD	ZC3H14 →	+0.488	+0.232	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,348 associations by consensus.

AKT1 vs TMED10 — BRCA

Explore this scatter interactively →