AKT1

Across TCGA pan-cancer cohorts, AKT1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AKT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKT1 is over-expressed in tumor, although a few such as LUAD and STAD show the opposite, repressed pattern.

HNSC, BRCA, and COAD are the cancer types where AKT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+1.041	<.001	12	view →
BRCA	All	II,III,IV	+0.476	<.001	8	view →
COAD	Female	All	+0.435	<.001	7	view →
UCEC	All	All	+0.488	.001	6	view →
STAD	Male	II,III,IV	+0.765	.001	5	view →
CHOL	All	II,III,IV	+1.339	.004	4	view →
BLCA	Female	All	+0.571	.009	3	view →
LUAD	All	II,III,IV	−0.260	.015	3	view →
KICH	Female	II,III,IV	+0.587	.004	2	view →
ESCA	All	All	+0.531	.002	2	view →
LIHC	Female	II,III,IV	+0.523	.010	2	view →
PRAD	All	All	+0.222	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AKT1–HNSC

Open the HNSC breakdown →