AKT1

Across TCGA patient cohorts, AKT1 mutation is significantly associated with the RNA expression of many other genes, with 1,873 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AKT1-associated genes across cancer lineages are PRAMEF2, RNU6-1140P, and MIR4804. Each is linked with AKT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKT1-to-partner and partner-to-AKT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF2 grouped by AKT1-low versus AKT1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT1→partner) and Y-score (partner→AKT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRAMEF2 →	+0.098	+3.650	.003	.006	3	3
CESC	RNU6-1140P →	+0.551	+4.124	<.001	.001	3	3
CESC	MIR4804 →	+0.280	+3.345	.004	.008	3	3
BRCA	SPINK4 →	+0.723	+3.831	.004	<.001	3	3
BRCA	GAD1 →	+0.532	+1.828	.003	.003	3	3
UCEC	SULT1C2P1 →	+0.481	+2.032	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,873 associations by consensus.

PRAMEF2 by AKT1 expression — LUSC

Explore this box plot interactively →