AKT1

Across TCGA patient cohorts, AKT1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKT1-associated genes across cancer lineages are JNK2, PR, and JNK_pT183_Y185. Each is linked with AKT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKT1-to-partner and partner-to-AKT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by AKT1-low versus AKT1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT1→partner) and Y-score (partner→AKT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JNK2 →	+0.192	+1.920	.026	.010	3	3
UCEC	PR →	+0.180	+2.807	.046	.003	3	3
BRCA	JNK_pT183_Y185 →	+0.177	+1.906	.049	.017	3	2
UCEC	PTEN →	+0.336	+1.700	.018	.042	3	2
UCEC	MSH6 →	-0.446	-4.077	<.001	<.001	3	2
UCEC	PAI-1 →	-0.361	-1.925	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK2 by AKT1 expression — BRCA

Explore this box plot interactively →