AKT1

Across TCGA cell cohorts, AKT1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKT1-associated genes across cancer lineages are GPR174, OR52Z1, and GPHB5. Each is linked with AKT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKT1-to-partner and partner-to-AKT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR174 grouped by AKT1-low versus AKT1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT1→partner) and Y-score (partner→AKT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR174 →	+0.023	+4.017	<.001	.007	3	1
BLOOD_Leukemia	OR52Z1 →	+0.047	+4.969	<.001	.003	3	1
BLOOD_Leukemia	GPHB5 →	+0.062	+4.539	<.001	.007	3	1
BLOOD_Leukemia	HTR3D →	+0.014	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GPR174 by AKT1 expression — OESOPHAGUS

Explore this box plot interactively →