AKR7A3

Across TCGA patient cohorts, AKR7A3 mutation is significantly associated with the RNA expression of many other genes, with 582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR7A3-associated genes across cancer lineages are RPS29P32, LINC00463, and LINC00458. Each is linked with AKR7A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR7A3-to-partner and partner-to-AKR7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by AKR7A3-low versus AKR7A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A3→partner) and Y-score (partner→AKR7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.488	+2.599	<.001	.009	3	2
UCEC	LINC00463 →	+0.247	+2.454	<.001	.004	3	2
UCEC	LINC00458 →	+0.374	+2.291	<.001	.009	3	2
SKCM	ELMO2P1 →	+0.059	+2.609	<.001	.009	3	1
SKCM	AQP7P5 →	+0.072	+3.395	<.001	.002	3	1
SKCM	RN7SL607P →	+0.161	+3.127	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 582 associations by consensus.

RPS29P32 by AKR7A3 expression — UCEC

Explore this box plot interactively →