AKR7A2

Across TCGA patient cohorts, AKR7A2 protein abundance is significantly associated with the RNA expression of many other genes, with 22,564 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR7A2-associated genes across cancer lineages are SKA1, HJURP, and NUF2. Each is linked with AKR7A2 in more than 7 cancer types. Because this analysis shows association rather than direction, both AKR7A2-to-partner and partner-to-AKR7A2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR7A2 versus SKA1 in BRCA, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A2→partner) and Y-score (partner→AKR7A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SKA1 →	-1.090	-0.443	<.001	<.001	3	8
BRCA	HJURP →	-1.195	-0.372	<.001	<.001	3	7
LUAD	NUF2 →	-0.999	-0.182	<.001	<.001	3	7
LUAD	CKAP2L →	-1.024	-0.207	<.001	<.001	3	7
LUAD	TTK →	-1.221	-0.228	<.001	<.001	3	7
BRCA	PLSCR4 →	+0.937	+0.298	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,564 associations by consensus.

AKR7A2 vs SKA1 — BRCA

Explore this scatter interactively →