AKR7A2

Across TCGA pan-cancer cohorts, AKR7A2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AKR7A2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AKR7A2 RNA is repressed in tumor relative to normal tissue. In most cancer types AKR7A2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LIHC are the cancer types where AKR7A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR7A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.261	<.001	10	view →
KIRP	Male	III,IV	−0.945	<.001	10	view →
LIHC	Female	All	+0.560	<.001	7	view →
THCA	Male	All	−0.285	<.001	7	view →
LUSC	All	All	+0.306	<.001	5	view →
BLCA	All	III,IV	+0.384	.012	4	view →
UCEC	All	All	−0.568	.011	2	view →
BRCA	All	III,IV	+0.345	.029	2	view →
HNSC	All	All	+0.168	.035	2	view →
LUAD	All	All	+0.167	.026	2	view →
COAD	All	IV	−0.401	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

AKR7A2–KICH

Open the KICH breakdown →