AKR7A2

Across TCGA patient cohorts, AKR7A2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR7A2-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and PCNA. Each is linked with AKR7A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR7A2-to-partner and partner-to-AKR7A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by AKR7A2-low versus AKR7A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A2→partner) and Y-score (partner→AKR7A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.362	+3.000	.015	.037	3	1
UCEC	mTOR_pS2448 →	-0.178	-3.000	.039	.037	3	1
UCEC	PCNA →	+0.323	+3.000	.009	.037	3	1
UCEC	PDCD4 →	-0.797	-3.000	.003	.037	3	1
UCEC	PKC-b-II_pS660 →	-0.382	-3.000	.017	.037	3	1
UCEC	ATM →	-0.844	-3.000	.001	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by AKR7A2 expression — UCEC

Explore this box plot interactively →