AKR1C6P

Across TCGA patient cohorts, AKR1C6P mutation is significantly associated with the RNA expression of many other genes, with 1,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C6P-associated genes across cancer lineages are HIKESHI, HIRIP3, and SLC2A13. Each is linked with AKR1C6P in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C6P-to-partner and partner-to-AKR1C6P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIKESHI grouped by AKR1C6P-low versus AKR1C6P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C6P→partner) and Y-score (partner→AKR1C6P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIKESHI →	+0.502	+3.459	.002	.005	3	1
UCEC	HIRIP3 →	+0.585	+3.202	.003	.009	3	1
UCEC	SLC2A13 →	+0.596	+3.369	<.001	.005	3	1
UCEC	TWF1 →	+0.815	+3.459	.005	.005	3	1
UCEC	GPATCH11 →	+0.660	+3.365	<.001	.004	3	1
UCEC	MERTK →	+1.027	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,040 associations by consensus.

HIKESHI by AKR1C6P expression — UCEC

Explore this box plot interactively →