AKR1C6P

Across TCGA pan-cancer cohorts, AKR1C6P RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of AKR1C6P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKR1C6P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKR1C6P is over-expressed in tumor, although a few such as THCA and CHOL show the opposite, repressed pattern.

HNSC, THCA, and CHOL are the cancer types where AKR1C6P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1C6P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.172	.002	10	view →
THCA	All	All	−0.213	<.001	7	view →
CHOL	All	All	−3.545	<.001	5	view →
COAD	All	All	+0.117	.001	5	view →
LUSC	All	All	+0.264	.004	4	view →
ESCA	All	II,III,IV	+0.380	.029	2	view →
LUAD	All	All	+0.193	.005	2	view →
BRCA	All	III,IV	−0.105	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

AKR1C6P–HNSC

Open the HNSC breakdown →