Across TCGA patient cohorts, AKR1C3 mutation is significantly associated with the RNA expression of many other genes, with 943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C3-associated genes across cancer lineages are PLBD2, MFSD12, and TUB. Each is linked with AKR1C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C3-to-partner and partner-to-AKR1C3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C3→partner) and Y-score (partner→AKR1C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLBD2 →	+0.455	+3.343	.005	.005	3	2
UCEC	MFSD12 →	+0.454	+3.507	.008	.002	3	2
UCEC	TUB →	-0.748	-4.000	.005	<.001	3	2
UCEC	KATNAL2 →	-0.825	-2.684	<.001	.006	3	2
UCEC	PRIMA1 →	-1.215	-3.700	<.001	.001	3	2
UCEC	ZNF454 →	-0.309	-3.394	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 943 associations by consensus.

Exploration

AKR1C3 survival (RNA) · tumor vs normal (RNA) · all AKR1C3 data types