AKR1C2

Across TCGA cell cohorts, AKR1C2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,775 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible AKR1C2-associated GO terms across cancer lineages are Testosterone biosynthetic process, Cellular response to jasmonic acid stimulus, and Response to jasmonic acid. Each is linked with AKR1C2 in more than 18 cancer types. Because this analysis shows association rather than direction, both AKR1C2-to-partner and partner-to-AKR1C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Testosterone biosynthetic process grouped by AKR1C2-low versus AKR1C2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C2→partner) and Y-score (partner→AKR1C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Testosterone biosynthetic process →	+1.884	+6.904	<.001	<.001	3	19
BREAST	Cellular response to jasmonic acid stimulus →	+1.897	+4.500	<.001	<.001	3	19
BREAST	Response to jasmonic acid →	+1.897	+4.500	<.001	<.001	3	19
LIVER	Terpenoid catabolic process →	+1.850	+7.102	<.001	<.001	3	17
BREAST	Response to prostaglandin D →	+1.339	+3.752	<.001	<.001	3	17
BREAST	Cellular response to prostaglandin D stimulus →	+1.339	+3.752	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,775 associations by consensus.

Testosterone biosynthetic process by AKR1C2 expression — LIVER

Explore this box plot interactively →