AKR1C2

Across TCGA pan-cancer cohorts, AKR1C2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated AKR1C2 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher AKR1C2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AKR1C2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

STAD, KIRP, and KIRC are the cancer types where AKR1C2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.235	0.531	<.001	108	view →
KIRP	DFS	Median	All	0.789	0.918	.001	52	view →
KIRC	DFS	Quartile	IV	0.774	0.221	.001	49	view →
MESO	DFS	Quartile	III,IV	0.622	0.269	.005	28	view →
HNSC	DFS	Quartile	II,III,IV	0.509	0.725	.010	18	view →
LGG	DFS	Tertile	All	0.796	0.677	.006	17	view →
LIHC	DFS	Median	All	0.488	0.617	.009	15	view →
UVM	DFS	Tertile	All	0.521	0.925	.016	15	view →
LAML	DFS	Median	All	0.274	0.527	.030	14	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	13	view →
BRCA	OS	Tertile	IV	0.379	0.793	.021	13	view →
OV	OS	Quartile	II,III,IV	0.791	0.890	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

AKR1C2–STAD (OS)

Open the STAD breakdown →