AKR1B1P8

Across TCGA pan-cancer cohorts, AKR1B1P8 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated AKR1B1P8 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher AKR1B1P8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AKR1B1P8 expression acts as an unfavorable survival marker, although some lineages such as ACC and HNSC show a favorable association.

MESO, LUAD, and ACC are the cancer types where AKR1B1P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.069	0.580	<.001	108	view →
LUAD	OS	Tertile	III,IV	0.147	0.679	.001	57	view →
ACC	OS	Tertile	III,IV	1.000	0.318	.008	54	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	27	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	27	view →
UCEC	DFS	Tertile	All	0.300	0.671	.022	24	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
LGG	OS	Tertile	All	0.223	0.461	.020	12	view →
HNSC	DFS	Tertile	IV	0.901	0.561	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

AKR1B1P8–MESO (OS)

Open the MESO breakdown →